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The gray matter remains normal in all characteristics while the white matter changes texture, becoming soft and gelatinous. Rarefaction of the white matter is seen through light microscopy and the small number of axons and U-fibers that were affected can also be seen. Numerous small cavities in the white matter are also apparent.
White matter refers to areas of the central nervous system that are mainly made up of myelinated axons, also called tracts. [1] Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distribution of action potentials , acting as a relay and coordinating communication between different brain regions.
The anti-mog spectrum in children is equally variated: Out of a sample of 41 children with MOG-antibodies 29 had clinical NMOSD (17 relapsing), 8 had ADEM (4 relapsing with ADEM-ON), 3 had a single clinical event CIS, and 1 had a relapsing tumefactive disorder. Longitudinal myelitis was evident on MRI in 76[percent].
Demyelinating diseases/disorders have been found worldwide in various animals. Some of these animals include mice, pigs, cattle, hamsters, rats, sheep, Siamese kittens, and a number of dog breeds (including Chow Chow, Springer Spaniel, Dalmatian, Samoyed, Golden Retriever, Lurcher, Bernese Mountain Dog, Vizsla, Weimaraner, Australian Silky ...
The white matter in preterm born children is particularly vulnerable during the third trimester of pregnancy when white matter developing takes place and the myelination process starts around 30 weeks of gestational age. [3]
While all leukodystrophies are the result of genetic mutations, [3] other demyelinating disorders have an autoimmune, infectious, or metabolic etiology. [ 4 ] When damage occurs to white matter, subsequent immune responses can lead to inflammation in the central nervous system (CNS), along with the loss of myelin.
The white matter of the brain, the Leydig cells of the testes and the adrenal cortex are the most severely affected systems. [1] The excess VLCFA can be detected in almost all tissues of the body, despite the localization of symptoms. [ 1 ]
There is no causal evidence to support the hypothesis that problems in labor contribute to the development of softening in infant white matter. [8] Also, further evidence shows a possible connection between low sugar and high protein levels in cerebral spinal fluid that can contribute to disease or virus susceptibility leading to cerebral ...