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Tazarotene, sold under the brand name Tazorac, among others, is a third-generation prescription topical retinoid. [2] [3] It is primarily used for the treatment of plaque psoriasis and acne. [4] Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. [4] It is a member of the acetylenic class of retinoids. [4]
Third generation retinoids have narrow biological roles due to their constrained structure, with adapalene mimicking the effects of isotretinoin, [12] bexarotene binding only the Retinoid X receptors, and tazarotene binding the Retinoic acid receptor beta and Retinoic acid receptor gamma forms.
It combines 0.01% halobetasol propionate (a corticosteroid that reduces inflammation and suppresses the immune system) and 0.045% tazarotene (a retinoid that promotes normal skin cell turnover and has anti-inflammatory effects) in a lotion formulation.
Tazarotene (Tazorac®): Prevents skin cells from building up and reduces inflammation, though it can be irritating Using a moisturizer alongside a retinoid is usually recommended to avoid over ...
Unlike the retinoid tretinoin (Retin-A), adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure. [19] Furthermore, photodegradation of the molecule is less of a concern in comparison to tretinoin and tazarotene. [7]
This article showcases a curated list of standout studies over the last week on topics such as cholesterol, GLP-1 drugs for weight loss, and supplements for heart health.
Nearly 30% of raw ingredients used to make critical drugs come from China, according to the hospital lobbying group, which represents almost 5,000 U.S. hospitals and healthcare systems. A third of ...
Bexarotene is a retinoid that selectively activates retinoid X receptors (RXRs), as opposed to the retinoic acid receptors, the other major target of retinoic acid (the acid form of vitamin A). [12] [13] [14] By so doing it induces cell differentiation and apoptosis and prevents the development of drug resistance. [15]
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