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Norethisterone enanthate (NETE), also known as norethindrone enanthate, is a form of hormonal birth control which is used to prevent pregnancy in women. [1] [2] [3] It is used both as a form of progestogen-only injectable birth control and in combined injectable birth control formulations. It may be used following childbirth, miscarriage, or ...
[73] [89] [90] Intramuscular injections of 200 mg norethisterone enanthate once every 3 weeks have also been found to suppress spermatogenesis in men. [81] [91] Similarly, a single intramuscular injection of 50 mg norethisterone enanthate in combination with 5 mg estradiol valerate has been found to strongly suppress testosterone levels in men ...
Norethisterone enanthate (brand names NET EN, Noristerat, Norigest, Doryxas) [5] – 200 mg (intramuscularly) every 2 months [3] Mechanism of action.
Estradiol valerate/norethisterone enantate (EV/NETE), sold under the brand name Mesigyna among others, is a form of combined injectable birth control which is used to prevent pregnancy in women.
Norethisterone (3-ketolynestrenol), the active metabolite of lynestrenol.. Lynestrenol itself does not bind to the progesterone receptor and is inactive as a progestogen. [7] [8] It is a prodrug, and upon oral administration, is rapidly and almost completely converted into norethisterone, a potent progestogen, in the liver during first-pass metabolism.
A single intramuscular injection of estradiol valerate/norethisterone enanthate (5 mg/50 mg) (Mesigyna) has been found to strongly suppress testosterone levels in men. [33] Testosterone levels decreased from a baseline of ~503 ng/dL to a trough of ~30 ng/dL (a 94% decrease) which occurred at day 7 post-injection. [33]
Norethisterone and 5α-DHNET have been found to act as weak irreversible aromatase inhibitors (K i = 1.7 μM and 9.0 μM, respectively). [7] However, the concentrations required are probably too high to be clinically relevant at typical dosages of norethisterone.
Estradiol undecylate/norethisterone enanthate (EU/NETE) is a combination medication of estradiol undecylate (EU), an estrogen, and norethisterone enanthate (NETE), a progestin, which was developed by Schering for potential use as a combined injectable contraceptive in women but was ultimately never marketed.