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Low sodium intake level was a mean of <115 mmol (2645 mg), usual sodium intake was 115-215 mmol (2645–4945 mg), and a high sodium intake was >215 mmol (4945 mg), concluding: "Both low sodium intakes and high sodium intakes are associated with increased mortality, consistent with a U-shaped association between sodium intake and health outcomes".
[14] There has been evidence from epidemiological studies, human and animal intervention experiments supporting the links between high rate of salt intake and hypertension. [2] [15] A Cochrane review and meta-analysis of clinical trials showed that reduced sodium intake reduces blood pressure in hypertensive and normotensive subjects.
Estimated sodium intake ≥6 g/day and <3 g/day are both associated with high risk of death or major cardiovascular disease, but the association between high sodium intake and adverse outcomes is only observed in people with hypertension. [103]
“Zero dietary sodium intake may lead to clinically significant low blood sodium levels, which can cause severe muscle cramps, weakness, nausea and vomiting, seizures and coma, shock or even ...
Mineralcorticoid excess due to a disease state such as Conn's syndrome usually does not lead to hypernatremia unless free water intake is restricted. Salt poisoning is the most common cause in children. [16] [17] It has also been seen in a number of adults with mental health problems. [11] Too much salt can also occur from drinking seawater or ...
Diabetic coma is a medical emergency in which a person with diabetes mellitus is comatose (unconscious) because of one of the acute complications of diabetes: [24] [25] Severe diabetic hypoglycemia Diabetic ketoacidosis advanced enough to result in unconsciousness from a combination of severe hyperglycemia , dehydration and shock , and exhaustion
Chronic hyperglycemia (high blood sugar) injures the heart in patients without a history of heart disease or diabetes and is strongly associated with heart attacks and death in subjects with no coronary heart disease or history of heart failure. [22] Also, a life-threatening consequence of hyperglycemia can be nonketotic hyperosmolar syndrome. [16]
According to 2021 data by the CDC, approximately 38.4 million people (11.6% of the U.S. population) have diabetes, 8.7 million of whom were undiagnosed but met laboratory criteria for diabetes ...