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Triethylamine is the chemical compound with the formula N(CH 2 CH 3) 3, commonly abbreviated Et 3 N. Like triethanolamine and tetraethylammonium , it is often abbreviated TEA. [ 8 ] [ 9 ] It is a colourless volatile liquid with a strong fishy odor reminiscent of ammonia .
Tetraethylammonium (TEA) is a quaternary ammonium cation with the chemical formula [Et 4 N] +, consisting of four ethyl groups (−C 2 H 5, denoted Et) attached to a central nitrogen atom. It is a counterion used in the research laboratory to prepare lipophilic salts of inorganic anions.
In organic chemistry, the Swern oxidation, named after Daniel Swern, is a chemical reaction whereby a primary or secondary alcohol (−OH) is oxidized to an aldehyde (−CH=O) or ketone (>C=O) using oxalyl chloride, dimethyl sulfoxide (DMSO) and an organic base, such as triethylamine.
A chemical equation is the symbolic representation of a chemical reaction in the form of symbols and chemical formulas.The reactant entities are given on the left-hand side and the product entities are on the right-hand side with a plus sign between the entities in both the reactants and the products, and an arrow that points towards the products to show the direction of the reaction. [1]
As the name suggests, a non-nucleophilic base is a sterically hindered organic base that is a poor nucleophile.Normal bases are also nucleophiles, but often chemists seek the proton-removing ability of a base without any other functions.
The strength of the electron-withdrawing group is inversely proportional to the pKa of the carboxylic acid. [2] The inductive effect is cumulative: trichloroacetic acid is 1000x stronger than chloroacetic acid. The impact of the EWG on pKa decreases with distances from the carboxylic group.
Like other simple aliphatic amines, ethylamine is a weak base: the pK a of [CH 3 CH 2 NH 3] + has been determined to be 10.8 [8] [9] Ethylamine undergoes the reactions anticipated for a primary alkyl amine, such as acylation and protonation. Reaction with sulfuryl chloride followed by oxidation of the sulfonamide give diethyldiazene, EtN=NEt. [10]
DIPEA is a sterically hindered organic base that is commonly employed as a proton scavenger. Thus, like 2,2,6,6-tetramethylpiperidine and triethylamine, DIPEA is a good base but a poor nucleophile, DIPEA has low solubility in water, which makes it very easily recovered in commercial processes, a combination of properties that makes it a useful organic reagent.