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Malignant hyperthermia is diagnosed on clinical grounds, but various laboratory investigations may prove confirmatory. These include a raised creatine kinase level, elevated potassium, increased phosphate (leading to decreased calcium) and—if determined—raised myoglobin; this is the result of damage to muscle cells.
patients with active hepatic disease; patients in whom spasticity is utilized to maintain upright posture and balance; patients with a hypersensitivity to dantrolene; There are no contraindications for intravenous dantrolene used for prophylaxis or management of malignant hyperthermia. [14]
As a result, it is contraindicated for patients with susceptibility to malignant hyperthermia, denervating conditions, major burns after 48 hours, and severe hyperkalemia. For nondepolarizing NMBAs except vecuronium, pipecuronium, doxacurium, cisatracurium, rocuronium and rapacuronium, they produce certain extent of cardiovascular effect. [ 14 ]
Lymphoma and a variety of autoimmune diseases, although it may be ineffective in treating IgA-mediated diseases. [ 13 ] Cardiac arrest , cytokine release syndrome , tumor lysis syndrome and acute kidney injury , infections, [ 14 ] hepatitis B reactivation, immune toxicity, pulmonary toxicity, [ 15 ] bowel obstruction and perforation [ 16 ] [ 17 ...
The diagnosis is suggested on patients with a history of drug exposure to the most common inducing agents such as strong antidopaminergic medications. [6] [40] The differential diagnosis includes serotonin syndrome, [41] encephalitis, toxic encephalopathy, status epilepticus, heat stroke, catatonia and malignant hyperthermia.
Agent concentration measurement: anaesthetic machines typically have monitors to measure the percentage of inhalational anaesthetic agents used as well as exhalation concentrations. These monitors include measuring oxygen , carbon dioxide , and inhalational anaesthetics (e.g., nitrous oxide , isoflurane ).
Methohexital or methohexitone (marketed under the brand names Brevital and Brietal) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. [2]
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. [1] In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time.