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3598 16165 Ensembl ENSG00000123496 ENSMUSG00000031289 UniProt Q14627 O88786 RefSeq (mRNA) NM_000640 NM_008356 NM_001306059 RefSeq (protein) NP_000631 NP_001292988 NP_032382 Location (UCSC) Chr X: 115 – 115.02 Mb Chr X: 146.17 – 146.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of ...
There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined. [3]
A major application of cellular adoptive therapy is cancer treatment, as the immune system plays a vital role in the development and growth of cancer. [1] The primary types of cellular adoptive immunotherapies are T cell therapies. Other therapies include CAR-T therapy, CAR-NK therapy, macrophage-based immunotherapy and dendritic cell therapy.
Now, research has identified a potential new therapy for Alzheimer’s — xenon gas. In a mouse model, researchers found that xenon gas inhalation suppressed neuroinflammation and reduced brain ...
A regenerative medicine therapy is defined in section 506(g)(8) of the FD&C Act to include cell therapies, therapeutic tissue engineering, human cell and tissue products. Under the FDA's interpretation, gene therapies and genetically modified cells that have a lasting effect, such as CAR-T antitumor therapies, may also qualify as regenerative ...
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Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, interferon type II, interferon type III.
Engineered chimeric antigen receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer-targeting therapeutic system of the CAR-T cell to the human body. CAR-T cells, which utilizes genetic modification of human T-cells to contain antigen binding sequences in addition to the receptor systems CD4 or CD8 , are ...