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Peptide amphiphiles were developed in the 1990s. They were first described by the group of Matthew Tirrell in 1995. [5] [6] These first reported PA molecules were composed of two domains: one of lipophilic character and another of hydrophilic properties, which allowed self-assembly into sphere-like supramolecular structures as a result of the association of the lipophilic domains away from the ...
These assemblies have shown promise as agents of drug delivery to cancer cells. Encapsulation can control reactivity. For instance, excited state reactivity of free 1-phenyl-3-tolyl-2-proponanone (abbreviated A-CO-B) yields products A-A, B-B, and AB, which result from decarbonylation followed by random recombination of radicals A• and B•.
Ultrasound-triggered drug delivery using stimuli-responsive hydrogels refers to the process of using ultrasound energy for inducing drug release from hydrogels that are sensitive to acoustic stimuli. This method of approach is one of many stimuli-responsive drug delivery-based systems that has gained traction in recent years due to its ...
A notable system in this category is a nanotubular supramolecular polymer formed by the supramolecular polymerization of amphiphilic hexa-peri-hexabenzocoronene (HBC) derivatives. [26] Generally, nanotubes are categorized as 1D objects morphologically, however, their walls adopt a 2D geometry and therefore require a different design strategy ...
Supramolecular chemistry refers to the branch of chemistry concerning chemical systems composed of a discrete number of molecules.The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small relative to the ...
The term supramolecular chemistry is defined by Jean-Marie Lehn as "the chemistry of intermolecular bond, covering structures and functions of the entities formed by association of two or more chemical species" in his Nobel lecture in 1987, [5] but the concept of supramolecular catalysis was started way earlier in 1946 by Linus Pauling when he ...
IUPAC defines a pharmacophore to be "an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target and to trigger (or block) its biological response". [1] A pharmacophore model explains how structurally diverse ligands can bind to a common receptor site.
Compared to single-headed amphiphiles, the introduction of a second head-group generally induces a higher solubility in water, an increase in the critical micelle concentration (CMC), and a decrease in aggregation number. The aggregate morphologies of bolaamphiphiles include spheres, cylinders, disks, and vesicles.