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Enterochromaffin-like cells (ECL cells) are a population of cells that are found in the gastric glands of the stomach luminal epithelium and secrete histamine. In response to gastrin released by neighbouring G-cells, secreted histamine from ECL cells acts on parietal cells to stimulate the release of gastric acid.
Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cell found in the gastric glands of the gastric mucosa beneath the epithelium, in particular in the vicinity of parietal cells, that aid in the production of gastric acid via the release of histamine. They are also considered a type of enteroendocrine cell. [1]
Serotonin (5-HT) is found widely distributed throughout the gut and the central nervous system. In the gut, 5-HT is found mostly in mucosal enterochromaffin cells. Enterochromaffin cells are sensory transducers that release 5-HT to activate intrinsic (via 5-HT1P and 5-HT 4 receptors) and extrinsic (via 5-HT 3 receptors) primary afferent nerves ...
Enterochromaffin-like cells are enteroendocrine and neuroendocrine cells also known for their similarity to chromaffin cells secreting histamine, which stimulates G cells to secrete gastrin. Other hormones produced include cholecystokinin , somatostatin , vasoactive intestinal peptide , substance P , alpha and gamma-endorphin .
These cells almost fill the tube and the remaining lumen is continued as a very fine channel. Cells found in the gastric glands include mucous neck cells, chief cells, parietal cells, G cells, and enterochromaffin-like cells (ECLs). The first cells of all of the glands are mucus-secreting foveolar cells that line the gastric pits.
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Several types of endocrine cells are found in the gastric glands. The pyloric glands contain gastrin-producing cells ; this hormone stimulates acid production from the parietal cells. Enterochromaffin-like cells (ECLs), found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion.
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