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BRCA1 is a human tumor suppressor gene [7] [8] (also known as a caretaker gene) ... DNA cross-linking agents are an important source of chromosome/DNA damage.
BRISC and BRCA1-A complex member 2 is a protein in humans encoded by the BABAM2 gene. References. a b c a b c; This ...
Inheriting one BRCA1 mutation and one BRCA2 mutation has been reported occasionally; the child's risk for any given type of cancer is the higher risk of the two genes (e.g., the ovarian cancer risk from BRCA1 and the pancreatic cancer risk from BRCA2). Inheriting two BRCA2 mutations produces Fanconi anemia. [9]: 82–85
BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of ...
72399 Ensembl ENSG00000089234 ENSMUSG00000029458 UniProt Q7Z569 Q99MP8 RefSeq (mRNA) NM_006768 NM_001289543 NM_001289544 NM_028227 RefSeq (protein) NP_006759 NP_001276472 NP_001276473 NP_082503 Location (UCSC) Chr 12: 111.64 – 111.69 Mb Chr 5: 121.8 – 121.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA1 associated protein is a protein that in humans is encoded by the BRAP ...
"It's very rare for a BRCA1 carrier to have breast cancer younger than age 25," Nicolette Chun, a genetics counselor at the Stanford Cancer Institute, said. "If there is a family history of breast ...
•List of human protein-coding genes page 2 covers genes EPHA1–MTMR3 •List of human protein-coding genes page 3 covers genes MTMR4–SLC17A7 •List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol.
BRCC36, the protein product of the BRCC3 gene, is a deubiquitinating enzyme and a core component of the deubiquitin complex BRCA1-A. [8] BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks.