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The chromosomal location of BRCA1 was discovered by Mary-Claire King's team at UC Berkeley in 1990. [21] After an international race to refine the precise location of BRCA1, [22] the gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics.
Inheriting one BRCA1 mutation and one BRCA2 mutation has been reported occasionally; the child's risk for any given type of cancer is the higher risk of the two genes (e.g., the ovarian cancer risk from BRCA1 and the pancreatic cancer risk from BRCA2). Inheriting two BRCA2 mutations produces Fanconi anemia. [9]: 82–85
72399 Ensembl ENSG00000089234 ENSMUSG00000029458 UniProt Q7Z569 Q99MP8 RefSeq (mRNA) NM_006768 NM_001289543 NM_001289544 NM_028227 RefSeq (protein) NP_006759 NP_001276472 NP_001276473 NP_082503 Location (UCSC) Chr 12: 111.64 – 111.69 Mb Chr 5: 121.8 – 121.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA1 associated protein is a protein that in humans is encoded by the BRAP ...
BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene. [5] [6] [7] Repair of DNA damage. BRE, the protein product of the BRE (gene), is a ...
BRISC and BRCA1-A complex member 2 is a protein in humans encoded by the BABAM2 gene. References. a b c a b c; This page was last edited on 1 October 2024, at 12:59 ...
GT198 is located at the long arm of human chromosome 17 (17q21). GT198 spans 5.5 kilobase pairs (Kb) and contains eight exons. GT198 is located 470 Kb proximal to BRCA1 and 2.9 megabase pairs (Mb) distal to Her2/neu between the two cancer genes. It is currently unknown if genetic instability of each gene could affect neighboring cancer genes.
Breast self-exams, she says, are a critical way that every person with female anatomy can be proactive about their own health. Only you can decide if conducting a breast self-exam is right for you.
Mary-Claire King (born February 27, 1946) [1] is an American geneticist.She was the first to show that breast cancer can be inherited due to mutations in the gene she called BRCA1.