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Fatigue in a medical context is used to cover experiences of low energy that are not caused by normal life. [2] [3]A 2021 review proposed a definition for fatigue as a starting point for discussion: "A multi-dimensional phenomenon in which the biophysiological, cognitive, motivational and emotional state of the body is affected resulting in significant impairment of the individual's ability to ...
Main symptoms of multiple sclerosis Symptoms and findings in multiple sclerosis. The signs and symptoms of multiple sclerosis (MS) encompass a wide range of neurological and physical manifestations, including vision problems, muscle weakness, coordination difficulties, and cognitive impairment, varying significantly in severity and progression among individuals.
Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.
fatigue – this is common in autoimmune diseases, and is the patient's primary concern [9] malaise; fever [10] These can be the initial presentation for some patients. [3] Other symptoms associated with UCTD include : [11] joint pain – the most common symptom, occurring in up to 86% of patients. [3]
Fibromyalgia is a medical syndrome that causes chronic widespread pain, accompanied by fatigue, awakening unrefreshed, and cognitive symptoms.Other symptoms can include headaches, lower abdominal pain or cramps, and depression. [9]
Muscle fatigue is when muscles that were initially generating a normal amount of force, then experience a declining ability to generate force. It can be a result of vigorous exercise , but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction .
Directed attention fatigue (DAF) is a neuro-psychological phenomenon that results from overuse of the brain's inhibitory attention mechanisms, which handle incoming distractions while maintaining focus on a specific task. The greatest threat to a given focus of attention is competition from other stimuli that can cause a shift in focus.
If the presynaptic vesicles are released at a faster rate into the synaptic cleft than re-uptake can recycle them, synaptic fatigue begins to occur. Synaptic fatigue , or short-term synaptic depression , is an activity-dependent form of short term synaptic plasticity that results in the temporary inability of neurons to fire and therefore ...