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Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active. [6] [7] Prednisolone then binds to glucocorticoid receptors, activating them and triggering changes in gene expression. [4] Prednisone was patented in 1954 and approved for medical use in the United States in 1955.
[10] Prednisolone was discovered and approved for medical use in 1955. [10] It is on the World Health Organization's List of Essential Medicines. [11] It is available as a generic drug. [6] In 2022, it was the 136th most commonly prescribed medication in the United States, with more than 4 million prescriptions. [12] [13]
A variety of steroid medications, from anti-allergy nasal sprays (Nasonex, Flonase) to topical skin creams, to eye drops , to prednisone have been implicated in the development of central serous retinopathy (CSR). [6] [7] Corticosteroids have been widely used in treating people with traumatic brain injury. [8]
List of steroid esters; List of steroid medications available in the United States; References ... This page was last edited on 10 October 2024, at 10:05 (UTC).
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Methyltestosterone (Android 5, Android 10, Android 25, Metandren, Oreton, Oreton Methyl, Testred, Virilon) Oxymetholone (Anadrol-50) Oxandrolone (Anavar) (Note that while the above anabolic steroids remain available in at least one formulation, many of the above-listed brand names have been discontinued.)
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Large dosage variations in the patient's medication (including a self-increased dosage from 10 mg/day to as much as 100 mg/day for at least 3 months) produced extreme behavioral changes, from missed appointments to physical altercations, and eventually admission to a psychiatric ward and later to a locked Alzheimer facility.