Search results
Results from the WOW.Com Content Network
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method. For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Considerations about reproducibility can be placed into two categories. Reproducibility in the narrow sense refers to re-examining and validating the analysis of a given set of data. Replication refers to repeating an existing experiment or study using new, independent data with the goal of verifying the original conclusions.
Pharmacology is the science of drugs and medications, [1] including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. [ 2 ]
Csaba Szabo, a physician and pharmacologist, is the Head of the Pharmacology Section and President of the Department of Oncology, Microbiology and Immunology (OMI) of the University of Fribourg in Switzerland. [1] The Public Library of Science Magazine, PLOS Biology, recognized Szabo in 2019 as one of the most cited researchers in the world. [2]
The Reproducibility Project is a series of crowdsourced collaborations aiming to reproduce published scientific studies, finding high rates of results which could not be replicated. It has resulted in two major initiatives focusing on the fields of psychology [ 1 ] and cancer biology. [ 2 ]
David Colquhoun FRS MAE (born 19 July 1936) is a British pharmacologist at University College London (UCL). [5] He has contributed to the general theory of receptor and synaptic mechanisms, and in particular the theory and practice of single ion channel function.
In determining bioequivalence between two products such as a commercially available Branded product and a potential to-be-marketed Generic product, pharmacokinetic studies are conducted whereby each of the preparations are administered in a cross-over study (sometimes parallel study, when a cross-over study is not feasible) to volunteer subjects, generally healthy individuals but occasionally ...