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For years, doctors recommended that older adults at a higher risk for heart attack or stroke take a low-dose aspirin once a day to lower their risk.
The American Heart Association’s current recommendation is that no one should take daily low-dose aspirin without talking to their doctor first, especially if they have an aspirin intolerance ...
Older adults are still likely to take a daily, low dose aspirin for the primary prevention of cardiovascular disease, even though doing so carries significant risks. Using aspirin to ward off ...
However, more recent trials were not able to replicate similar outcomes using low dose aspirin in low body weight (<70 kg) in specific subset of population studied i.e. elderly and diabetic population, and more evidence is required to study the effect of high dose aspirin in high body weight (≥70 kg). [107] [108] [109]
Low-dose, long-term aspirin use irreversibly blocks the formation of thromboxane A 2 in platelets, producing an inhibitory effect on platelet aggregation. [13] This effect is mediated by the irreversible blockage of COX-1 in platelets, since mature platelets don't express COX-2. [14]
However, low-dose aspirin (75-100 mg) might be considered for primary prevention of atherosclerotic cardiovascular disease (ASCVD) among select adults 40-70 years of age who are deemed to be at ...
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