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Allotransplant (allo-meaning "other" in Greek) is the transplantation of cells, tissues, or organs to a recipient from a genetically non-identical donor of the same species. [1] The transplant is called an allograft, allogeneic transplant, or homograft. Most human tissue and organ transplants are allografts.
[2] Allograft bone is a logical alternative to autograft. However, it must be rigorously processed and terminally sterilized prior to implantation to remove the risk of disease transmission or an immunological response. This processing removes the osteogenic and osteoinductive properties of the graft, leaving only an osteoconductive scaffold ...
An allograft contains many of the beneficial characteristics of nerve autograft, such as three-dimensional microstructural scaffolding and protein components inherent to nerve tissue. [3] One of the adverse effects of nerve allotransplantation is the immunogenic response.
Liver transplantation is a potential treatment for acute or chronic conditions which cause irreversible and severe ("end-stage") liver dysfunction. [4] Since the procedure carries relatively high risks, is resource-intensive, and requires major life modifications after surgery, it is reserved for dire circumstances.
Allograft offers the best regeneration quality but has lower volume stability. Often a mix of different kinds of bone grafts is used. [citation needed] In general, bone graft is either used en bloc (such as from the chin or the ascending ramus area of the lower jaw) or particulated, in order to be able to adapt it better to a defect.
A syngeneic graft is known as an isograft. [2] Related terms include: [citation needed] autogeneic, referring to autotransplantation, also termed autograft, (from one part of the body to another in the same person) allogeneic, referring to allotransplantation or an allograft (from other individual of same species).
[2] The practice of tissue transplantation dates back to 1600 BC and has undergone vast advancements since then. The four main types of tissue transplantation are xenotransplantation, allotransplantation, isotransplantation and autotransplantation, while the common tissues transplanted include skin, bone, corneal and vessel grafts.
Transplant engineering (or allograft engineering) is a variant of genetic organ engineering which comprises allograft, autograft and xenograft engineering. In allograft engineering the graft is substantially modified by altering its genetic composition. The genetic modification can be permanent or transient.