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Cerefolin is a prescription medication made by Pamlab that contains 5.635 mg of folate as L-methylfolate, 1 mg of vitamin B 12 as methylcobalamin, 50 mg of vitamin B 2 as riboflavin, and 5 mg of vitamin B 6 as pyridoxine. It is approved by the U.S. Food and Drug Administration for the treatment or prevention of vitamin deficiencies. [1]
Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B 9), methylcobalamin (vitamin B 12) and pyridoxal 5'-phosphate (vitamin B 6). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN). [1]
L-Methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml). [3]
[5] [3] The gelators may precipitate and salt out, and some drugs may degrade in gel formulation due to the other ingredients present in the formulation. [ 5 ] Some additives and gelators added into the formulation may cause irritation problems, [ 5 ] [ 8 ] such as skin irritation, dermatitis or allergic conditions . [ 2 ]
Liquid bandage is typically a polymer dissolved in a solvent (commonly water or an alcohol), sometimes with an added antiseptic and local anesthetic, although the alcohol in some brands may serve the same purpose. [1] These products protect the wound by forming a thin film of polymer when the carrier evaporates. [1]
Silicone gel sheet consists of a soft, semi-occlusive sheet and a membrane that increases the durability of the sheet. [3] The sheet has a solid rubber-like appearance. Although the mechanism of action of silicone gel sheeting remains partially unknown, its efficacy is confirmed by many clinical trials, [5] and is similar to silicone gel. [6]
A container with cream. Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons, waxes, or polyethylene glycols as the vehicle for external skin application. [1]
The gel may be designed to drain, or to remain within the structure of the adhesive matrix. [ 4 ] The moist conditions produced under the dressing are intended to promote fibrinolysis , angiogenesis and wound healing, without causing softening and breaking down of tissue.
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