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Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10] [12] is the S(+) enantiomer of ketamine. [5] [13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression.
A new study compares ketamine with electroconvulsive therapy in people with treatment-resistant depression. The researchers identify subsets of people who respond better to ketamine and vice versa.
Ketamine and depression: How it works. Although experts are still investigating the precise mechanisms involved in ketamine’s antidepressant effects, the picture is growing clearer.
Ketamine is under investigation for its potential in treating treatment-resistant depression. [ 166 ] [ 167 ] [ 168 ] Ketamine is a known psychoplastogen , which refers to a compound capable of promoting rapid and sustained neuroplasticity .
Since depression comes in many forms, treating this mental health condition isn’t a one-size-fits-all approach. With a wide variety of treatment methods, it can take time to find the one that ...
Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]
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