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The only form of ketamine that is FDA-approved for treatment-resistant depression is Spravato, which includes one molecule of ketamine and only comes in the form of a nasal spray.
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Ketamine is under investigation for its potential in treating treatment-resistant depression. [ 165 ] [ 166 ] [ 167 ] Ketamine is a known psychoplastogen , which refers to a compound capable of promoting rapid and sustained neuroplasticity .
A new study compares ketamine with electroconvulsive therapy in people with treatment-resistant depression. The researchers identify subsets of people who respond better to ketamine and vice versa.
The researchers looked at data on 424 people with treatment-resistant depression who were treated between November 2017 and May 2021 at three ketamine infusion clinics in Virginia that specialize ...
Ketamine and depression: How it works. Although experts are still investigating the precise mechanisms involved in ketamine’s antidepressant effects, the picture is growing clearer.
Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]
In 2019, the FDA approved a nasal spray called esketamine, which is derived from ketamine, as a medication for depression that does not respond to traditional methods of treatment, like SSRIs ...
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