Search results
Results from the WOW.Com Content Network
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954.
ALT is usually found only in the liver. AST is most commonly found in the liver, but also in significant amounts in heart and skeletal muscle. [citation needed] Measurement of ALT and AST were used in diagnosing heart attacks, although they have been replaced by newer enzyme and protein tests that are more specific for cardiac damage.
AST exists in two isoenzymes namely mitochondrial form and cytoplasmic form. It is found in highest concentration in the liver, followed by heart, muscle, kidney, brain, pancreas, and lungs. [ 10 ] This wide range of AST containing organs makes it a relatively less specific indicator of liver damage compared to ALT.
The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
ALT is found in plasma and in various body tissues but is most common in the liver. It catalyzes the two parts of the alanine cycle . Serum ALT level, serum AST ( aspartate transaminase ) level, and their ratio ( AST/ALT ratio ) are routinely measured clinically as biomarkers for liver health.
The four top national leaders of the Proud Boys, convicted for seditious conspiracy for Jan. 6 but now freed by Trump, say they have lofty goals.
Animals must metabolize proteins to amino acids, at the expense of muscle tissue, when blood sugar is low. The preference of liver transaminases for oxaloacetate or alpha-ketoglutarate plays a key role in funneling nitrogen from amino acid metabolism to aspartate and glutamate for conversion to urea for excretion of nitrogen.
AST Research, Inc., as known as AST Computer, a personal computer manufacturer Asti , Italian province and city (was traditionally Ast in the Piemontese dialect) Assured shorthold tenancy , UK