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  2. High-throughput screening - Wikipedia

    en.wikipedia.org/wiki/High-throughput_screening

    High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [ 2 ] [ 3 ] Using robotics , data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to ...

  3. Phenotype microarray - Wikipedia

    en.wikipedia.org/wiki/Phenotype_microarray

    High-throughput phenotypic testing is increasingly important for exploring the biology of bacteria, fungi, yeasts, and animal cell lines such as human cancer cells.Just as DNA microarrays and proteomic technologies have made it possible to assay the expression level of thousands of genes or proteins all a once, phenotype microarrays (PMs) make it possible to quantitatively measure thousands of ...

  4. Phenotypic screening - Wikipedia

    en.wikipedia.org/wiki/Phenotypic_screening

    High-content screening where changes in the expression of several proteins can be simultaneously monitored is also often used. [9] [10] High-content imaging of dye-labeled cellular components can also reveal effects of compounds on cell cultures in vitro, distinguishing the phenotypic effects of a broad variety of drugs. [11]

  5. High throughput biology - Wikipedia

    en.wikipedia.org/wiki/High_throughput_biology

    Classical High throughput screening robotics are now being tied closer to cell biology, principally using technologies such as High-content screening.High throughput cell biology dictates methods that can take routine cell biology from low scale research to the speed and scale necessary to investigate complex systems, achieve high sample size, or efficiently screen through a collection.

  6. Hit selection - Wikipedia

    en.wikipedia.org/wiki/Hit_selection

    In high-throughput screening (HTS), one of the major goals is to select compounds (including small molecules, siRNAs, shRNA, genes, et al.) with a desired size of inhibition or activation effects. A compound with a desired size of effects in an HTS screen is called a hit.

  7. High-content screening - Wikipedia

    en.wikipedia.org/wiki/High-content_screening

    Given the increase in the use of phenotypic/visual screening as a cell biological tool, methods are required that permit systematic biochemical target identification if these molecules are to be of broad use. [6] Target identification has been defined as the rate limiting step in chemical genetics/high-content screening. [7]

  8. Marker-assisted selection - Wikipedia

    en.wikipedia.org/wiki/Marker-assisted_selection

    Marker assisted selection or marker aided selection (MAS) is an indirect selection process where a trait of interest is selected based on a marker (morphological, biochemical or DNA/RNA variation) linked to a trait of interest (e.g. productivity, disease resistance, abiotic stress tolerance, and quality), rather than on the trait itself.

  9. Omics - Wikipedia

    en.wikipedia.org/wiki/Omics

    Ethomics: The high-throughput machine measurement of animal behaviour. [ 27 ] Videomics (or vide-omics): A video analysis paradigm inspired by genomics principles, where a continuous image sequence (or video) can be interpreted as the capture of a single image evolving through time through mutations revealing 'a scene'.