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  2. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    Sleep deprivation and light therapy both target the same brain neurotransmitter system and brain areas as antidepressant drugs, and are now used clinically to treat depression. [28] Light therapy, sleep deprivation and sleep time displacement (sleep phase advance therapy) are being used in combination quickly to interrupt a deep depression in ...

  3. Kindling hypothesis of depression - Wikipedia

    en.wikipedia.org/wiki/Kindling_hypothesis_of...

    The kindling hypothesis of depression posits that each period of depression in someone with major depressive disorder (MDD) causes neurological changes that predispose the person to future episodes. While the first episode of depression is often triggered by major life events, future episodes are less likely to be tied to circumstantial factors ...

  4. Long-term depression - Wikipedia

    en.wikipedia.org/wiki/Long-term_depression

    In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.

  5. Evolutionary approaches to depression - Wikipedia

    en.wikipedia.org/wiki/Evolutionary_approaches_to...

    One reason depression is thought to be a pathology is that it causes so much psychic pain and distress. However, physical pain is also very distressful, yet it has an evolved function: to inform the organism that it is being damaged, to motivate it to withdraw from the source of damage, and to learn to avoid such damage-causing circumstances in the future.

  6. Major depressive disorder - Wikipedia

    en.wikipedia.org/wiki/Major_depressive_disorder

    Depression due to physical illness is diagnosed as a mood disorder due to a general medical condition. This condition is determined based on history, laboratory findings, or physical examination . When the depression is caused by a medication, non-medical use of a psychoactive substance, or exposure to a toxin , it is then diagnosed as a ...

  7. Epigenetics of depression - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_depression

    Epigenetics of depression is the study of how epigenetics (heritable characteristics that do not involve changes in DNA sequence) contribute to depression. Major depressive disorder is heavily influenced by environmental and genetic factors.

  8. Depression after a brain injury is a distinct condition ... - AOL

    www.aol.com/news/depression-brain-injury...

    Depression after a traumatic brain injury, such as a concussion, may be a distinct condition, different from other types of depression. That could change treatment. Depression after a brain injury ...

  9. Behavioral theories of depression - Wikipedia

    en.wikipedia.org/wiki/Behavioral_theories_of...

    Depression is a significant mental illness with physiological and psychological consequences, including sluggishness, diminished interest and pleasure, and disturbances in sleep and appetite. [1] It is predicted that by the year 2030, depression will be the number one cause of disability in the United States and other high-income countries. [2]

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