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The active ingredients are imidacloprid, permethrin, and pyriproxyfen. This product is toxic to cats, [2] and it is not recommended to use it on dogs which share an environment with cats. [1] The product is applied onto the skin; administration of the product into the mouth can cause adverse effects. [3]
Imidacloprid and its nitrosoimine metabolite (WAK 3839) have been well studied in rats, mice and dogs. In dogs the LD 50 is 450 mg/kg of body weight (i.e., in any sample of medium-sized dogs weighing 13 kilograms (29 lb), half of them would be killed after consuming 5,850 mg of imidacloprid, or about 1 ⁄ 5 th of an ounce).
Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats. [2] It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.
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Imidacloprid can be added to the water used to irrigate plants. Controlled-release formulations of imidacloprid take 2–10 days to release 50% of imidacloprid in water. [ 36 ] It is applied against soil pests, seed, timber, and animal pests as well as foliar treatments.
A comparison of 3 insecticides (selamectin, fipronil, imidacloprid) showed that selamectin reduced larval cat fleas ≥93.5% after 24 h at doses of ≥0.3 μg. In contrast, at 24 h neither fipronil nor imidacloprid reached 90% reduction, even at the highest doses tested (0.5 μg for fipronil and 5.0 μg for imidacloprid).
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