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In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA.This process, known as mRNA capping, is highly regulated and vital in the creation of stable and mature messenger RNA able to undergo translation during protein synthesis.
The National Coalition on Aging has contracted with up to 150 senior centers to help older adults get COVID-19 and flu vaccines and is helping to administer the vaccines at 180 community-based ...
An NBC News analysis shows that fewer than half of the people 50 and up — those authorized Tuesday for a second Covid-19 booster shot — will be eligible for that shot by mid-May. People 50 ...
The CHMP recommends authorizing Moderna's (MRNA) bivalent COVID-19 booster vaccine, targeting the Omicron BA.4/5 subvariants, for use in adults and adolescents aged 12 years and older.
It consists of a five-prime cap; a five prime untranslated region derived from the sequence of human alpha globin; a signal peptide (bases 55–102) and two proline substitutions (K986P and V987P, designated "2P") that cause the spike to adopt a prefusion-stabilized conformation reducing the membrane fusion ability, increasing expression and ...
A CDC advisory committee recommended boosters of Moderna and Johnson & Johnson, and endorsed a "mix and match" approach to booster shots.
The NAD+ 5' cap has been observed in bacteria, [3] contrary to the long-held belief that prokaryotes lacked 5'-capped RNA, [4] as well as on the 5' cap of eukaryotic mRNA, [5] in place of the m7G cap. This modification also potentially allows for selective degradation of RNA]within prokaryotes as different pathways are involved in the ...
“The Moderna vaccine is a very similar vaccine to the Pfizer vaccine, so I would anticipate an approval for that could follow shortly,” said Dr. Christina Rostad, an assistant professor of ...
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