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In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA.This process, known as mRNA capping, is highly regulated and vital in the creation of stable and mature messenger RNA able to undergo translation during protein synthesis.
The CHMP recommends authorizing Moderna's (MRNA) bivalent COVID-19 booster vaccine, targeting the Omicron BA.4/5 subvariants, for use in adults and adolescents aged 12 years and older.
There are three different COVID vaccines to choose from this season: two mRNA vaccines from Pfizer and Moderna, and a protein-based vaccine from Novavax. These vaccines replace the previous COVID ...
A CDC advisory committee recommended boosters of Moderna and Johnson & Johnson, and endorsed a "mix and match" approach to booster shots.
It consists of a five-prime cap; a five prime untranslated region derived from the sequence of human alpha globin; a signal peptide (bases 55–102) and two proline substitutions (K986P and V987P, designated "2P") that cause the spike to adopt a prefusion-stabilized conformation reducing the membrane fusion ability, increasing expression and ...
In August 2021, the FDA and the CDC authorized the use of an additional mRNA vaccine dose for immunocompromised individuals. [318] [319] The authorization was extended to cover other specific groups in September 2021. [320] [321] [322] In October 2021, the FDA and the CDC authorized the use of either homologous or heterologous vaccine booster ...
This week the Biden administration announced it was recommending booster shots of the Moderna and Pfizer vaccines for many Americans as early as Sept. 20. COVID-19 vaccine booster shots: What you ...
The NAD+ 5' cap has been observed in bacteria, [3] contrary to the long-held belief that prokaryotes lacked 5'-capped RNA, [4] as well as on the 5' cap of eukaryotic mRNA, [5] in place of the m7G cap. This modification also potentially allows for selective degradation of RNA]within prokaryotes as different pathways are involved in the ...
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