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Ramipril, a prodrug or precursor drug, is converted to the active metabolite ramiprilat by carboxylesterase 1. [ 17 ] [ 18 ] Ramiprilat is mostly excreted by the kidneys . Its half-life is variable (3–16 hours), and is prolonged by heart and liver failure , as well as kidney failure .
Amlodipine works partly by vasodilation (relaxing the arteries and increasing their diameter). [10] It is a long-acting calcium channel blocker of the dihydropyridine type. [10] Amlodipine was patented in 1982, and approved for medical use in 1990. [12] It is on the World Health Organization's List of Essential Medicines. [13]
The trust was formed on 1 October 2024 following the merger of Solent NHS Trust and Southern Health NHS Foundation Trust and also incorporates the community and mental health services formerly provided by the Isle of Wight NHS Trust. The merger was approved in November 2023 and was originally planned for April 2024, but was delayed twice. [1] [2]
Tameside and Glossop Integrated Care NHS Foundation Trust is an integrated foundation Trust that operates from Tameside General Hospital situated in Ashton-under-Lyne.It serves the surrounding area of Tameside in Greater Manchester, and the town of Glossop and other smaller towns and villages in the north western part of the High Peak district of Derbyshire.
It received praise for brevity, being only 39 pages, and lacking the illustrations which had graced its predecessors. Like the NHS Plan 2000 with which Stevens was also associated it was supported by the great and good of the NHS, but in this case it was regulators - Monitor, the Care Quality Commission and the like, rather than the Royal Colleges and Trades Unions of the earlier plan.
Lisinopril/amlodipine, sold under the brand name Lisonorm among others, is a medication used to treat high blood pressure. [1] It is a combination of lisinopril, an ACE inhibitor,with amlodipine, a calcium channel blocker. [1] It may be used when blood pressure is not well controlled with each of the two agents alone. [4] It is taken by mouth. [1]
The NHS Long Term Plan, also known as the NHS 10-Year Plan is a document published by NHS England on 7 January 2019, which sets out its priorities for healthcare over the next 10 years and shows how the NHS funding settlement will be used. It was published by NHS England chief executive Simon Stevens and Prime Minister Theresa May. [1]
The trust took over some services run by North Cumbria University Hospitals NHS Trust in 2016. Children's services were the first. [12] The trust was one of the beneficiaries of Boris Johnson's announcement of capital funding for the NHS in August 2019, with an allocation of £41,7 million for improving paediatric cardiac services. [13]
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