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The main symptom of benign fasciculation syndrome is focal or widespread involuntary muscle activity (fasciculation). [1] The benign twitches usually have a constant location. [2] Other common symptoms are generalized fatigue or weakness, paraesthesia or numbness, and muscle cramping or spasms. [1]
A fasciculation, or muscle twitch, is a spontaneous, involuntary muscle contraction and relaxation, involving fine muscle fibers. [1] They are common, with as many as 70% of people experiencing them. [1] They can be benign, or associated with more serious conditions. [1]
C fibers respond to all kinds of physiological changes in the body. [8] For example, they can respond to hypoxia, hypoglycemia, hypo-osmolarity, the presence of muscle metabolic products, and even light or sensitive touch. [8] C fiber receptors include: C fiber nociceptors responsible for the second, burning pain; C fiber warming specific receptors
Paresthesia, also known as pins and needles, is an abnormal sensation of the skin (tingling, pricking, chilling, burning, numbness) with no apparent physical cause. [1] ...
The following table describes the IENFD values in males and females of a 3 mm biopsy 10 cm above the lateral malleolus (above ankle outer side of leg). [21] Any value measured below the 0.05 Quantile IENFD values per age span, is considered a reliable positive diagnosis for small fiber peripheral neuropathy. [21]
Involuntary extension of the "normal" leg occurs when flexing the contralateral leg against resistance. To perform the test, the examiner should hold one hand under the heel of the "normal" limb and ask the patient to flex the contralateral hip against resistance (while the patient is supine), asking the patient to keep the weak leg straight while raising it.
Dysesthesia is an unpleasant, abnormal sense of touch. Its etymology comes from the Greek word "dys," meaning "bad," and "aesthesis," which means "sensation" (abnormal sensation). It often presents as pain [1] but may also present as an inappropriate, but not discomforting, sensation.
[3] [8] [5] [2] [6] [4] (The term "meralgia paraesthetica" combines four Greek roots to mean "thigh pain with abnormal sensations".) Examples of paresthesias (abnormal sensations but not unpleasant) and dysthesias (abnormal sensations that are unpleasant) are burning, tingling, numbness, stinging, hypersensitivity, and itching.