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Allergies to cats, a type of animal allergy, are one of the most common allergies experienced by humans.Among the eight known cat allergens, the most prominent allergen is secretoglobin Fel d 1, which is produced in the anal glands, salivary glands, and, mainly, in sebaceous glands of cats, and is ubiquitous in the United States, even in households without cats.
Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. [2] [3] Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.
Allergy testing can help confirm or rule out allergies and consequently reduce adverse reactions and limit unnecessary avoidance and medications. [1] [2]Correct allergy diagnosis, counseling and avoidance advice based on valid allergy test results is of utmost importance and can help reduce the incidence of symptoms, and the need for medications and improve quality of life. [2]
Allergies are caused by an oversensitive immune system, leading to a misdirected immune response. The immune system normally protects the body against harmful substances such as bacteria and viruses. Allergy occurs when the immune system reacts to substances that are generally harmless and in most people do not cause an immune response.
Food allergies account for approximately 10% of allergies in both dogs and cats. [5] Food allergies are often mistaken for food intolerances, which can result in vomiting and diarrhea instead of dermal issues. In most cases where food allergies occur, they do so with foods that cats eat most often. Common food allergens in cats include beef ...
Adults and children of any age can get an allergy blood test. For babies and very young children, a single needle stick for allergy blood testing is often gentler than several skin pricks. An allergy blood test is available through most laboratories. A sample of the patient's blood is sent to a laboratory for analysis, and the results are sent ...
A patch test relies on the principle of a type IV hypersensitivity reaction.. The first step in becoming allergic is sensitization. When skin is exposed to an allergen, the antigen-presenting cells (APCs) – also known as Langerhans cell or Dermal Dendritic Cell – phagocytize the substance, break it down to smaller components and present them on their surface bound major histocompatibility ...
The RAST is a radioimmunoassay test to detect specific IgE antibodies to suspected or known allergens for the purpose of guiding a diagnosis about allergy. [10] [11] IgE is the antibody associated with Type I allergic response: for example, if a person exhibits a high level of IgE directed against pollen, the test may indicate the person is allergic to pollen (or pollen-like) proteins.
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