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Lassa fever, also known as Lassa hemorrhagic fever, is a type of viral hemorrhagic fever caused by the Lassa virus. [1] Many of those infected by the virus do not develop symptoms . [ 1 ] When symptoms occur they typically include fever , weakness, headaches, vomiting , and muscle pains . [ 1 ]
Lassa virus life cycle. Figure by Fehling et al., 2012 [13] The life cycle of Lassa mammarenavirus is similar to the Old World arenaviruses. Lassa mammarenavirus enters the cell by the receptor-mediated endocytosis. Which endocytotic pathway is used is not known yet, but at least the cellular entry is sensitive to cholesterol depletion.
Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is ...
Bunyavirales is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. [2] It is the only order in the class Ellioviricetes. [1]
An arenavirus is a bi- or trisegmented ambisense RNA virus that is a member of the family Arenaviridae. [1] [2] These viruses infect rodents and occasionally humans.A class of novel, highly divergent arenaviruses, properly known as reptarenaviruses, have also been discovered which infect snakes to produce inclusion body disease, mostly in boa constrictors.
The nucleoprotein structure in Lassa virus (Arenaviridae) contains a second nuclease. Researchers propose that it is involved in attenuating interferon response, but it also contains a dTTP-binding site which may be used for cap-snatching. In this model, the L and N proteins cooperate in the cap-snatching process.
LCMV is a prototype of more severe hemorrhagic fever viruses, [8] especially Lassa virus with the greatest prevalence in sub-Saharan Africa. [8] However, other strains of this virus (Junin and Machupo viruses) [8] are present in parts of South America and other strains continue to significantly affect the southern African population. Since the ...
Viral evolution is a subfield of evolutionary biology and virology concerned with the evolution of viruses. [1] [2] Viruses have short generation times, and many—in particular RNA viruses—have relatively high mutation rates (on the order of one point mutation or more per genome per round of replication).
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