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The Hill equation reflects the occupancy of macromolecules: the fraction that is saturated or bound by the ligand. [1] [2] [nb 1] This equation is formally equivalent to the Langmuir isotherm. [3] Conversely, the Hill equation proper reflects the cellular or tissue response to the ligand: the physiological output of the system, such as muscle ...
The EC 50 represents the point of inflection of the Hill equation, beyond which increases of [A] have less impact on E. In dose response curves, the logarithm of [A] is often taken, turning the Hill equation into a sigmoidal logistic function. In this case, the EC 50 represents the rising section of the sigmoid curve.
If the deep marine hydrothermal setting was the site for the origin of life, then abiogenesis could have happened as early as 4.0-4.2 Gya. If life evolved in the ocean at depths of more than ten meters, it would have been shielded both from impacts and the then high levels of ultraviolet radiation from the sun.
Günter Wächtershäuser (born 1938 in Gießen) is a German chemist turned patent lawyer who is widely known for his work on the origin of life, and in particular his iron-sulfur world theory, a theory that life on Earth has hydrothermal origins.
While it is true that Miller-Urey setups produce racemic mixtures, [80] the origin of homochirality is a separate area in origin of life research. [ 81 ] Recent work demonstrates that magnetic mineral surfaces like magnetite can be templates for the enantioselective crystallization of chiral molecules, including RNA precursors , due to the ...
Hill equation may refer to Hill equation (biochemistry) Hill differential equation This page was last edited on 28 December 2019, at 18:37 (UTC). Text is available ...
Primordial soup, also known as prebiotic soup, is the hypothetical set of conditions present on the Earth around 3.7 to 4.0 billion years ago. It is an aspect of the heterotrophic theory (also known as the Oparin–Haldane hypothesis) concerning the origin of life, first proposed by Alexander Oparin in 1924, and J. B. S. Haldane in 1929.
Haldane's article on abiogenesis in 1929 introduced the "primordial soup theory", which became the foundation for the concept of the chemical origin of life. He established human gene maps for haemophilia and colour blindness on the X chromosome , and codified Haldane's rule on sterility in the heterogametic sex of hybrids in species .