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Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]
Spironolactone; Clinical data; Pronunciation / ˌ s p aɪ r oʊ n oʊ ˈ l æ k t oʊ n / SPY-roh-noh-LAK-tone, [1] / ˌ s p ɪər oʊ n oʊ ˈ l æ k t oʊ n / SPEER-oh-noh-LAK-tone [2] Trade names: Aldactone, others
Increased sodium reabsorption also increases water retention. [ 8 ] [ 9 ] Potassium-sparing diuretics act to prevent sodium reabsorption in the collecting tubule by either binding ENaCs (amiloride, triamterene) or by inhibiting aldosterone receptors (spironolactone, eplerenone).
Aldosterone antagonists: spironolactone, which is a competitive antagonist of aldosterone. Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. Spironolactone prevents aldosterone from entering the principal cells, preventing sodium reabsorption.
Aldosterone receptor antagonists, also known as mineralocorticoid receptor antagonist (MRA) can lower blood pressure by blocking the binding of aldosterone to the mineralocorticoid receptor. Spironolactone and eplerenone are MRAs that causes a block in the reabsorption of sodium, resulting in a decrease in blood pressure. [45] [46] eplerenone
Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Everything I Wish I Knew About ...
If you’re a side-sleeper or if you have trouble sleeping on your back, adding a pillow between your legs and keeping your back straight can still help reduce shortness of breath from chest ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261