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Spironolactone is sometimes able to significantly lower testosterone levels at high dosages in spite of not acting as an antigonadotropin, and this is thought to be due to direct enzymatic inhibition of 17α-hydroxylase and 17,20-lyase, enzymes necessary for the biosynthesis of testosterone.
Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. High testosterone levels are associated with other health conditions such as obesity, hypertension, amenorrhea (cessation of menstrual cycles), and ovulatory dysfunction, which can lead to infertility.
Because of its antiandrogenic activity, spironolactone can cause breast tenderness, gynecomastia (breast development), feminization in general, and demasculinization, as well as sexual dysfunction including loss of libido and erectile dysfunction, although these side effects are usually confined to high doses of spironolactone. [109] At very ...
High levels of androgens (AKA male hormones) play a role in PCOS. ... including testosterone, estrogen, luteinizing hormone, and anti-Mullerian hormone ... Medications like spironolactone and ...
High testosterone levels have been linked to various health issues, such as prostate cancer. In these scenarios, someone may consider anti-androgen medication and other lifestyle factors to reduce ...
1941: Hudgins and Hodges show that androgen deprivation via high-dose estrogen therapy or surgical castration treats prostate cancer; 1957: The steroidal antiandrogen spironolactone is first synthesized [219] 1960: Spironolactone is first introduced for medical use, as an antimineralocorticoid [219]
Spironolactone stops androgen from binding to receptors, which reduces testosterone and DHT levels and decreases hair loss. Women who are pregnant or trying to get pregnant shouldn’t take ...
Due to its progestogenic (and by extension antigonadotropic) activity, CPA is able to suppress circulating testosterone levels by 70 to 80% in men at high dosages. [25] [94] In contrast, NSAAs increase testosterone levels by up to 2-fold via blockade of the AR, a difference that is due to their lack of concomitant antigonadotropic action. [95]
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