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Low-dose spironolactone is generally very well tolerated. [62] Even higher doses of spironolactone, such as 100 mg/day, are well tolerated in most individuals. [62] Dose-dependent side effects of spironolactone include menstrual irregularities, breast tenderness, and enlargement, orthostatic hypotension, and hyperkalemia. [62]
Weight gain. Some side effects, such as weight gain, occur more frequently with certain types of antidepressant medication. Switching to a new type of antidepressant may help reverse any weight ...
In 2019 a systematic review compared the effects on weight of various doses of fluoxetine (60 mg/d, 40 mg/d, 20 mg/d, 10 mg/d) in obese and overweight adults. [55] When compared to placebo, all dosages of fluoxetine appeared to contribute to weight loss but lead to increased risk of experiencing side effects, such as dizziness, drowsiness ...
A 2012 meta-analysis of fluoxetine and venlafaxine concluded that statistically and clinically significant treatment effects were observed for each drug relative to placebo irrespective of baseline depression severity; some of the authors however disclosed substantial relationships with pharmaceutical industries.
The weight loss was comparable to that achieved with a 2.4 milligram dose of semaglutide injected once a week in the form of Wegovy over the same time frame, the company said in a statement.
The onset of action of the antimineralocorticoid effects of spironolactone is relatively slow, with the peak effect sometimes occurring 48 hours or more after the first dose. [1] [24] Canrenone is an antagonist of the MR as is spironolactone, [25] but it is slightly more potent in comparison.
On the flip side, while there isn't scientific evidence of negative effects of this nature at this point, there is some anecdotal evidence linking GLP-1s and a decreased enthusiasm and drive when ...
In 1994, sales of the combination drug Fen-phen (fenfluramine and phentermine) increased dramatically, as this combination produced substantial and apparent synergistic effect in promoting weight loss. Subsequently, reports of severe side effects associated with heart valve abnormalities and an increased risk of pulmonary hypertension resulted ...
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