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These cell-derived vesicles are specialized to initiate biomineralisation of the matrix in a variety of tissues, including bone, cartilage and dentin. During normal calcification , a major influx of calcium and phosphate ions into the cells accompanies cellular apoptosis (genetically determined self-destruction) and matrix vesicle formation.
The tissue of the seminal vesicles is full of glands, spaced irregularly. [8] As well as glands, the seminal vesicles contain smooth muscle and connective tissue. [8] This fibrous and muscular tissue surrounds the glands, helping to expel their contents. [3] The outer surface of the glands is covered in peritoneum. [3]
Exosomes are extracellular vesicles having a unique biogenesis pathway via multivesicular bodies. Exosome formation starts with the invagination of the multi-vesicular bodies (MVBs) or late endosomes to generate intraluminal vesicles (ILVs). [58] There are various proposed mechanisms for formation of MVBs, vesicle budding, and sorting.
GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac). GLUT4 is distinctive because it is predominantly stored within intracellular vesicles, highlighting the importance of its trafficking and regulation as a central area of research. [5]
Later, synaptic vesicles could also be isolated from other tissues such as the superior cervical ganglion, [40] or the octopus brain. [41] The isolation of highly purified fractions of cholinergic synaptic vesicles from the ray Torpedo electric organ [ 42 ] [ 43 ] was an important step forward in the study of vesicle biochemistry and function.
The decrease in pH by ATP6V1G2 in the vesicle is important in the function of vesicle binding to the SNARE protein and endocytosis. [13] Activation of a nerve causes lower pH in the vesicles, and a larger pH in the cell. [13] Calcium and hydrogen antiporters are required for ATP6V1G2 to acidify the inside of the vesicle. [13]
The yolk sac is a membranous sac attached to an embryo, formed by cells of the hypoblast layer of the bilaminar embryonic disc.This is alternatively called the umbilical vesicle by the Terminologia Embryologica (TE), though yolk sac is far more widely used.
The Golgi apparatus (/ ˈ ɡ ɒ l dʒ i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [1] Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.