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Ifosfamide is the most common cause of hemorrhagic cystitis. Radiation-induced hemorrhagic cystitis develops in similar or smaller patient numbers when compared to cyclophosphamide-induced cases. [3] Adenovirus (particularly serotypes 11 and 21 of subgroup B) is the most common cause of acute viral hemorrhagic cystitis in children, though it ...
Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, [18] bone marrow suppression, [19] stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin/nails, alopecia (hair loss) or thinning of hair, changes in color and texture of the hair ...
Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, in vivo , may be converted to urotoxic metabolites, such as acrolein .
Hemorrhagic cystitis, characterized by blood in the urine, can occur secondary to a number of causes including: infections, radiation therapy, underlying cancer, medications and toxins. [59] Medications that commonly cause this problem include the chemotherapeutic agent cyclophosphamide with rates of 2–40%. [59]
Immunosuppressive drugs, also known as immunosuppressive agents, ... High doses cause pancytopenia and hemorrhagic cystitis. Antimetabolites
Ifosfamide (IFO), sold under the brand name Ifex among others, is a chemotherapy medication used to treat a number of types of cancer. [2] This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. [2]
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In relation to interstitial cystitis, when noxious stimuli are present, it causes injury to the bladder mucosa resulting in recruitment of inflammatory cells. [3] Disruption of glycosaminoglycan (GAG) layer [ 14 ] along with the increased presence of mast cells , T cells , and B cells causes the bladder epithelium to become more permeable.