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Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
Glucosamine is naturally present in the shells of shellfish, animal bones, bone marrow, and fungi. [22] D-Glucosamine is made naturally in the form of glucosamine-6-phosphate, and is the biochemical precursor of all nitrogen-containing sugars. [23]
Cosequin comes in formulas specific for cats, dogs and horses. [2] According to the manufacturer Cosequin may be useful for pets with osteoarthritis (OA), but the efficacy is disputed. [3] Glucosamine is used in equine medicine, but little evidence indicates that it has any value in the treatment of joint disease in horses. [4]
Equine studies have shown that grapiprant is present in urine 96 hours after the first administration of a dose of 2 mg/kg and has a concentration >0.005 ng/ml. From the excreted dose conducted in horses, it is found that 55%, 15% and 19% of the orally-administered dose was excreted in bile, urine, and faeces respectively. [3]
The lethal dose for 50% of dogs is 100 – 200 mg per kilogram (kg) of body weight, yet some dogs will exhibit signs of toxicosis after ingesting as little as 20 mg per kg. [38] In case of accidental intake of chocolate, especially involving a smaller dog, contact a veterinarian or animal poison control immediately; it is commonly recommended ...
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