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The definition of the condition includes the requirement that the duodenal histological appearances are otherwise unremarkable, specifically with normal villous architecture. [2] In coeliac disease (also known as gluten-sensitive enteropathy), duodenal lymphocytosis is found in untreated or partially treated cases. This is the least severe type ...
Both anti-transglutaminase and anti-endomysial antibodies have high sensitivity to diagnose people with classic symptoms and complete villous atrophy, but they are only found in 30–89% of the cases with partial villous atrophy and in less than 50% of the people who have minor mucosal lesions (duodenal lymphocytosis) with normal villi. [23] [24]
Known causes of duodenitis include: [2] Helicobacter pylori infection; Coeliac disease; Bacterial infection; Viral infection; NSAIDs; Autoimmune diseases (i.e. Crohn's disease) Duodenal lymphocytosis; Idiopathic
Villous blunting; Crypt hypertrophy; Villous fusion; Mucosal inflammation; The key histological features are villous flattening, crypt hyperplasia and inflammation in the epithelium and lamina propria. [34] [40] However, this procedure is considered too invasive, complex and expensive to be implemented as standard of care. [2]
After surgery involving the stomach and duodenum (most commonly with Billroth II antrectomy), a blind loop may be formed, leading to stasis of flow of intestinal contents. This can cause overgrowth, and is termed blind loop syndrome. [23] Systemic or metabolic disorders may lead to conditions allowing bacterial overgrowth as well.
A new study has linked visceral fat around the midsection with an increased risk of developing Alzheimer’s disease
Histopathological features include small bowel villous changes such as atrophy and blunting, typically prominent in the proximal bowel. [12] Occasionally crypt abscesses are also seen. [ 50 ] The crypt epithelium may contain apoptotic bodies and lymphocytic infiltration, with comparatively little surface lymphocytosis (less than 40 lymphocytes ...
Some troops leave the battlefield injured. Others return from war with mental wounds. Yet many of the 2 million Iraq and Afghanistan veterans suffer from a condition the Defense Department refuses to acknowledge: Moral injury.