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Starvation response in animals (including humans) is a set of adaptive biochemical and physiological changes, triggered by lack of food or extreme weight loss, in which the body seeks to conserve energy by reducing metabolic rate and/or non-resting energy expenditure to prolong survival and preserve body fat and lean mass.
Basal metabolic rate (BMR) is the rate of energy expenditure per unit time by endothermic animals at rest. [1] It is reported in energy units per unit time ranging from watt (joule/second) to ml O 2 /min or joule per hour per kg body mass J/(h·kg).
The routine use of VLCDs is not recommended due to safety concerns, but this approach can be used under medical supervision if there is a clinical rationale for rapid weight loss in obese individuals, as part of a "multi-component weight management strategy" with continuous support and for a maximum of 12 weeks, according to the NICE 2014 guidelines. [12]
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Starvation is a severe deficiency in caloric energy intake, below the level needed to maintain an organism's life. It is the most extreme form of malnutrition. In humans, prolonged starvation can cause permanent organ damage [1] and eventually, death. The term inanition [2] refers to the symptoms and effects of starvation.
Energy intake is measured by the amount of calories consumed from food and fluids. [1] Energy intake is modulated by hunger, which is primarily regulated by the hypothalamus, [1] and choice, which is determined by the sets of brain structures that are responsible for stimulus control (i.e., operant conditioning and classical conditioning) and cognitive control of eating behavior.
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In ruminants, because dietary carbohydrates tend to be metabolized by rumen organisms, gluconeogenesis occurs regardless of fasting, low-carbohydrate diets, exercise, etc. [8] In many other animals, the process occurs during periods of fasting, starvation, low-carbohydrate diets, or intense exercise.