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TPO antibodies in the blood may mean you have thyroid disease due to an immune system condition called Hashimoto's disease. With Hashimoto's disease, the immune system makes antibodies that attack healthy tissue by accident. Antibodies that attack the thyroid can cause swelling, called inflammation, in the gland.
In an autoimmune disorder, the immune system produces rogue antibodies that target healthy cells or proteins in the body. Usually in Hashimoto's disease, the immune system produces an antibody to thyroid peroxidase (TPO), a protein that plays an important part in thyroid hormone production.
First, in way of background for those not familiar with anti-TPO antibodies: these are antibodies directed against the thyroid gland. They are most often measured in a patient with “subclinical” hypothyroidism (i.e. elevated TSH but normal free T4).
There are several reasons why we can't specify the range here on Health SE, especially for anti-TPO Ab. The test method; Antibodies are proteins, produced by our immune system. Determining the concentration of a specific protein is somewhat more difficult than determining the concentration of a smaller molecule.
Normal. A result of 9 where the reference range is 0 - 34 indicates that you're within the normal range. For this test, an abnormal result would be a value over 34 because it's not possible to have a result below zero. Keep in mind that each testing lab can different reference ranges, and they can differ over time too.
Your Graves-like lab results in the presense of TPO antibodies (especially without elevated TSI), rather than actually indicating Graves, most likely represent fluctuations in thyroid hormone release from ongoing autoimmune destruction of your thyroid. In all likelihood you will eventually develop Hashimoto's and need horomone replacement.
Hi all! Was wondering if anyone else has tpo & tg ab but all other labs in "normal" ranges. How are you being treated & what has the Dr dx'ed you with?
The presence of antinuclear antibodies is a positive test result. But having a positive result doesn't mean you have a disease. Many people with no disease have positive ANA tests — particularly women older than 65. Some infectious diseases and cancers have been associated with the development of antinuclear antibodies, as have certain drugs.
I would like some advice on the following lab work I had done because of various symtoms I have been having such as tiredness, hand tremors, cold intolerance, coarse hair, numb arms/hands, eyelids swelling, etc. TPO - 97 high (range 0-34) Antithyroglobulin Ab - 142 high (range 0-40) TSH 1.407 (range 0.45-4.500)
Treatment for hypothyroidism usually includes taking the thyroid hormone medicine levothyroxine (Levo-T, Synthroid, others) every day. This medicine is taken by mouth. It returns hormone levels to a healthy range, eliminating symptoms of hypothyroidism. You'll likely start to feel better one or two weeks after you begin treatment.