Search results
Results from the WOW.Com Content Network
The toxic dose of paracetamol is highly variable. In general the recommended maximum daily dose for healthy adults is 4 grams. [17] [18] Higher doses lead to increasing risk of toxicity. In adults, single doses above 10 grams or 200 mg/kg of bodyweight, whichever is lower, have a reasonable likelihood of causing toxicity.
For comparison, those with a V d L/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 132 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [ 6 ]
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
Listing price on eBay: $2,500 There were countless Japanese-made, cartoon-like ceramic figurines made during the 1950s, and some of the most valuable (and collectible) are vintage salt and pepper ...
Rumack Matthew Nomogram with treatment line added at 150. It is a semi-log plot with acetaminophen levels (on a logarithmic scale) along the vertical axis versus time (on a linear scale) along the horizontal axis.
"He wouldn't let me go inside. And he choked me (unintelligible) in the hallway," she said. "He blocked the door so I couldn't go inside, and when I did go inside, he chased me upstairs.