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Idiopathic multicentric Castleman disease (iMCD) is a subtype of Castleman disease (also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of lymphoproliferative disorders characterized by lymph node enlargement, characteristic features on microscopic analysis of enlarged lymph node tissue, and a range of symptoms and clinical findings.
Duration of symptoms can vary, and ranges between weeks to months following initial onset. [1] Unilateral lymph node involvement accounts for the majority of cases, and involvement of the cervical lymph nodes is the most common. [1] In addition to swollen lymph nodes, the person may experience mild fevers, decreased appetite, or weight loss. [5]
Buboes are also symptoms of other diseases, such as chancroid and lymphogranuloma venereum. [6] [7] In these conditions, a two-week course of antibiotics is the recommended treatment, and incision and drainage or excision of the swollen lymph nodes is best avoided. [8] [9] However, aspiration may sometimes be performed to prevent buboes from ...
On its way, the fluid passes through the lymph nodes, small nodular organs located throughout the body but concentrated in certain areas such as the armpits or groin. These lymph nodes are also known as glands or lymphoid tissue. If they detect something foreign passing through them, they enlarge. This is called lymphadenopathy or swollen glands.
Lymph nodes may become enlarged in malignant disease. This cervical lymphadenopathy may be reactive or metastatic. [1] Alternatively, enlarged lymph nodes may represent a primary malignancy of the lymphatic system itself, such as lymphoma (both Hodgkin's and non-Hodgkin's), [6] lymphocytic leukemia, [1] Lymphadenopathy that lasts less than two weeks or more than one year with no progressive ...
Sometimes symptoms stem are secondary to compression of surrounding structures by rapidly enlarging lymph nodes. Some UCD patients, however, experience systemic inflammatory symptoms such as fever, fatigue, night sweats, weight loss, and skin rash as well as laboratory abnormalities such as elevated C-reactive protein.
It is not the same as Hodgkin's Disease. Symptoms usually include painless, enlarged lymph node or nodes in the neck, weakness, fever, weight loss, and anemia. [citation needed] Lymphadenitis. Lymphadenitis is an infection of the lymph nodes usually caused by a virus, bacteria or fungi. Symptoms include redness or swelling around the lymph node.
The signs and symptoms of Kikuchi disease are fever, enlargement of the lymph nodes (lymphadenopathy), skin rashes, and headache. [7] In sixty to ninety percent of cases, lymphadenopathy presents in the posterior cervical lymph nodes with diameter enlargement typically being between one and two centimeters, but up to seven centimeters has been reported in literature.
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