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An mRNA molecule is said to be monocistronic when it contains the genetic information to translate only a single protein chain (polypeptide). This is the case for most of the eukaryotic mRNAs. [28] [29] On the other hand, polycistronic mRNA carries several open reading frames (ORFs), each of which is
Multicistronic message is an archaic term for Polycistronic. Monocistronic, bicistronic and tricistronic are also used to describe mRNA with single, double and triple coding areas (exons). Note that the base word cistron is no longer used in genetics, and has been replaced by intron and exon in eukaryotic mRNA. However, the mRNA found in ...
In the case of messenger RNA (mRNA) the RNA is an information carrier coding for the synthesis of one or more proteins. mRNA carrying a single protein sequence (common in eukaryotes) is monocistronic whilst mRNA carrying multiple protein sequences (common in prokaryotes) is known as polycistronic.
[63] [64] The genes in an operon are transcribed as a continuous messenger RNA, referred to as a polycistronic mRNA. The term cistron in this context is equivalent to gene. The transcription of an operon's mRNA is often controlled by a repressor that can occur in an active or inactive state depending on the presence of specific metabolites. [65]
Prokaryotic ribosomes begin translation of the mRNA transcript while DNA is still being transcribed. Thus translation and transcription are parallel processes. Bacterial mRNA are usually polycistronic and contain multiple ribosome binding sites. Translation initiation is the most highly regulated step of protein synthesis in prokaryotes.
Several ribosomes synthesizing a polypeptide on the same mRNA strand. A polyribosome (or polysome or ergosome) is a group of ribosomes bound to an mRNA molecule like “beads” on a “thread”. [1] It consists of a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptides.
Gene structure is the organisation of specialised sequence elements within a gene.Genes contain most of the information necessary for living cells to survive and reproduce. [1] [2] In most organisms, genes are made of DNA, where the particular DNA sequence determines the function of the gene.
The words cistron and gene were coined before the advancing state of biology made it clear to many people that the concepts they refer to, at least in some senses of the word gene, are either equivalent or nearly so. The same historical naming practices are responsible for many of the synonyms in the life sciences.