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Tenofovir disoproxil, sold under the brand name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. [4] It is generally recommended for use with other antiretrovirals. [4]
Emtricitabine/tenofovir is also used for HIV post-exposure prophylaxis. People who start taking emtricitabine/tenofovir see HIV reduction benefits up to 72 hours after starting, but the medicine must be taken for thirty days after a high-risk sexual event to ensure HIV transmission levels are optimally reduced. [21] [22]
Tenofovir alafenamide, sold under the brand name Vemlidy, is an antiviral medication used against hepatitis B and HIV. It is used for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease [ 8 ] and is given in combination with other medications for the prevention and treatment of HIV.
Tenofovir, also known as TDF is a so-called 'prodrug' with the active compound deactivated by a molecular side chain that dissolves in the human body allowing a low dose of tenofovir to reach the site of desired activity. One example of the prodrug form is tenofovir disoproxil fumarate with the trade name Viread (Gilead Sciences Inc USA).
Tenofovir alafenamide: Hepatitis B: Tenofovir disoproxil: Hepatitis B, HIV [19] Tipranavir: HIV Trifluridine: Eyes related Herpes Trizivir: HIV Tromantadine: Herpes Simplex Truvada: HIV Umifenovir: Influenza Valaciclovir (Valtrex) [20] Herpes Simplex/Zoster Valganciclovir (Valcyte) [21] Cytomegalovirus (CMV) Vicriviroc: HIV-1: Schering-Plough ...
Tenofovir alafenamide (TAF) is a prodrug of tenofovir that functions as a nucleotide reverse transcriptase inhibitor (NtRTI). Other prodrugs for tenofovir have been tested, but TAF is more efficient at refining HIV-1 therapy. It converts intracellularly to TFV diphosphate, which is a metabolite in HIV target cells. [19]
Tablets of Truvada, a tenofovir/emtricitabine combination used for HIV pre-exposure prophylaxis. Pre-exposure prophylaxis for HIV prevention, commonly known as PrEP, is the use of antiviral drugs as a strategy for the prevention of HIV/AIDS by people that do not yet have HIV/AIDS. [1]
[2] [3] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. [2] Use remains recommended after the first trimester. [2] Use is not recommended in those with kidney problems. [3] The combination is a type of antiretroviral therapy. [2]
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