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In molecular biology, treadmilling is a phenomenon observed within protein filaments of the cytoskeletons of many cells, especially in actin filaments and microtubules. It occurs when one end of a filament grows in length while the other end shrinks, resulting in a section of filament seemingly "moving" across a stratum or the cytosol.
Cryogenic grinding, also known as freezer milling, freezer grinding, and cryomilling, is the act of cooling or chilling a material and then reducing it into a small particle size. For example, thermoplastics are difficult to grind to small particle sizes at ambient temperatures because they soften, adhere in lumpy masses and clog screens.
The predominant artifact that degrades FIB tomography is ion mill curtaining, where mill patterns form large aperiodic stripes in each image. The ion mill curtaining can be removed using destriping algorithms. FIB tomography can be done at both room and cryo temperatures as well as on both materials and biological samples.
Misfolded proteins can form protein aggregates or amyloid fibrils, get degraded, or refold back to its native structure. In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly.
In form milling, the cutter called a form cutter travels axially along the length of the gear tooth at the appropriate depth to produce the gear tooth.After each tooth is cut, the cutter is withdrawn, the gear blank is rotated, and the cutter proceeds to cut another tooth.
The ion mill generates high-energy particles to remove material off the surface of a specimen, similar to how sand and dust particles wear away at rocks in a canyon to create a smooth surface. Relative to other techniques, ion milling creates much less surface damage, [1] which makes it perfect for surface-sensitive analytical techniques. This ...
Freeform surface milling. In manufacturing, freeform surface machining refers to the machining of complex surfaces that are not uniformly planar. The industries which most often manufactures free-form surfaces are basically aerospace, automotive, die mold industries, biomedical and power sector for turbine blades manufacturing.
Form-milling uses either a single- or multiple-form cutter. In one variant of form-milling, the single-form cutter is tilted to the helix angle of the thread and then fed radially into the blank. The blank is then slowly rotated as the cutter is precisely moved along the axis of the blank, which cuts the thread into the blank.