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Neurosyphilis is the infection of the central nervous system by Treponema pallidum, the bacterium that causes the sexually transmitted infection syphilis. In the era of modern antibiotics , the majority of neurosyphilis cases have been reported in HIV-infected patients.
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum , a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...
Pleocytosis, raised CSF protein level and positive CSF serology suggest neurosyphilis. [31] CSF VDRL is 50-90% specific for neurosyphilis. [18] 60% of newborns with congenital syphilis also have neurosyphilis. [18] Non-treponemal titers should be monitored in the newborns every 2-3 months to ensure an adequate response to treatment. [18]
Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
Acquired syphilis from a prostitute in the age of 21. [11] Bram Stoker (1847–1912), Irish author Cause of death listed as "Locomotor ataxia 6 months", presumed to be a reference to syphilis. [12] [13] Guy de Maupassant (1850–1893), French writer [14] Tongzhi Emperor (1856–1875), Emperor of Qing Dynasty Suspected to have had syphilis ...
By age, 62% of cases belonged collectively to two groups: 25–34 years and 45 years or above. Young people aged 15–24 accounted for 12% of reported cases. [14] Within the region, the country with the highest rate of reported cases was Malta at 32.2 per 100,000 population, while the lowest number was reported from Croatia, at 0.9 per 100,000 ...
General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
They are a highly specific sign of neurosyphilis; however, Argyll Robertson pupils may also be a sign of diabetic neuropathy. In general, pupils that accommodate but do not react are said to show light-near dissociation (i.e., it is the absence of a miotic reaction to light, both direct and consensual, with the preservation of a miotic reaction ...