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Normal individuals typically have around 2 to 8 G 4 C 2 repeats, but individuals with FTD or ALS have from 500 to several thousand G 4 C 2 repeats. [ 97 ] [ 98 ] The transcribed RNA of these repeats have been shown to form stable G-quadruplexes, with evidence showing that the G 4 C 2 repeats in DNA have the ability to form mixed parallel ...
DNAzyme research for the treatment of cancer is also underway. The development of a 10-23 DNAzyme that can block the expression of IGF-I (Insulin-like growth factor I, a contributor to normal cell growth as well as tumorigenesis) by targeting its mRNA could be useful for blocking the secretion of IGF-I from prostate storm primary cells ...
The bacterial type IV secretion system, also known as the type IV secretion system or the T4SS, is a secretion protein complex found in gram negative bacteria, gram positive bacteria, and archaea. It is able to transport proteins and DNA across the cell membrane. [1] The type IV secretion system is just one of many bacterial secretion systems.
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IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids.
Trial sparks uproar over rape convictions, justice system. Feminist leaders and activists said the case was also a searing indictment of the French legal system's handling of rape and sexual violence.
Examples include breathlessness, high blood pressure, knee or hip pain, reduced range of motion due to excess body fat, heart failure or other organ dysfunction. Children and adolescents with ...
Escherichia virus G4 is a bacteriophage that infects E. coli. [1] First isolated in 1973, the phage was originally isolated from samples of raw sewage and has 5,577 nucleotides. Its isometric capsid contains a single-stranded circular genome of about 5.5 kbp .