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The normochromic cells have a normal concentration of haemoglobin, and are therefore 'red enough' while the hypochromic cells do not; thus the value of the mean corpuscular hemoglobin concentration.The most common cause of microcytosis is iron deficiency anemia. Every time Hb synthesis being impaired in bone marrow microcytosis can occurs such ...
Microcytic anaemia; Microcytosis is the presence of red cells that are smaller than normal. Normal adult red cell has a diameter of 7.2 µm. Microcytes are common seen in with hypochromia in iron-deficiency anaemia, thalassaemia trait, congenital sideroblastic anaemia and sometimes in anaemia of chronic diseases.
Pinocytosis, also known as cell drinking, is the absorption of small aqueous particles along with the membrane receptors that recognize them.It is an example of fluid phase endocytosis and is usually a continuous process within the cell.
The most common causes of this kind of anemia are iron deficiency and thalassemia. Hypochromic anemia was historically known as chlorosis or green sickness for the distinct skin tinge sometimes present in patients, in addition to more general symptoms such as a lack of energy, shortness of breath, dyspepsia , headaches , a capricious or scanty ...
Reactive lymphocytes are usually associated with viral illnesses, but they can also be present as a result of drug reactions (such as phenytoin), immunizations, radiation, and hormonal causes (such as stress and Addison's disease), as well as some autoimmune disorders (such as rheumatoid arthritis). [7] Some pathogen-related causes include: [6]
Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst , leading to an insufficient number of oxygen-carrying red blood cells in circulation . The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in ...
Chemotherapeutic & Cytotoxic drugs 5-fluorouracil; Hydroxyurea; Hydroxycarbamide [6] Methotrexate [6] Following Granulocyte colony stimulating Factor (G-CSF) administration [5] Steroid therapy for immune thrombocytopenic purpura (ITP) [7] Iron deficiency anaemia
Autoimmune disease.; Thymoma. [2]Viral infections such as HIV, herpes, parvovirus B19 (Fifth disease), [3] or hepatitis. [citation needed]Lymphoproliferative.Association of pure red cell aplasia with T-cell large granular lymphocyte leukemia is well recognized, especially in China.