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Moclobemide is a benzamide, [13] derivative of morpholine, [98] which acts pharmacologically as a selective, reversible inhibitor of monoamine oxidase-A (RIMA), [10] a type of monoamine oxidase inhibitor (MAOI), and increases levels of norepinephrine (noradrenaline), dopamine, and especially serotonin [9] [99] in neuronal cells as well as in ...
Treatment in the initial state aims to attain an optimal tradeoff between good management of symptoms and side effects resulting from enhancement of dopaminergic function. The start of L-DOPA treatment may be delayed by using other medications such as MAO-B inhibitors and dopamine agonists, in the hope of delaying the onset of dyskinesias. [3]
Side effects of rasagiline include insomnia and orthostatic hypotension, among others. [2] Rasagiline acts as an inhibitor of the enzyme monoamine oxidase (MAO) and hence is a monoamine oxidase inhibitor (MAOI). [2] More specifically, it is a selective inhibitor of monoamine oxidase B (MAO-B). [2]
Compared to older antidepressants like monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), SSRIs like escitalopram tend to be safer and less likely to cause side effects or ...
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants , especially for treatment-resistant depression and atypical depression . [ 1 ]
The most common symptoms of primidone overdose are coma with loss of deep tendon reflexes, and during the recovery period, if the patient survives, disorientation, dysarthria, nystagmus, and ataxia, [51] lethargy, somnolence, vomiting, nausea, and occasionally, focal neurological deficits which lessen over time. [52]
While its half-life is only about 2 hours, its pharmacodynamic effects last several days to weeks due to irreversible inhibition of MAO. [ 20 ] Metabolites of tranylcypromine include 4-hydroxytranylcypromine, N -acetyltranylcypromine, and N -acetyl-4-hydroxytranylcypromine, which are less potent MAO inhibitors than tranylcypromine itself. [ 20 ]
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