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[2] [254] At 37 °C (98.6 °F), or normal human body temperature, bicalutamide is practically insoluble in water (4.6 mg/L), acid (4.6 mg/L at pH 1), and alkali (3.7 mg/L at pH 8). [ 27 ] [ 89 ] In organic solvents , it is slightly soluble in chloroform and absolute ethanol , sparingly soluble in methanol , and freely soluble in acetone and ...
However, the rates of these side effects with bicalutamide monotherapy are very low. [8] In the EPC trial, at 7.4 years follow-up, the rates of decreased libido and impotence were only 3.6% and 9.3% in the 150 mg/day bicalutamide monotherapy group relative to 1.2% and 6.5% for placebo, respectively. [8]
Prochlorperazine, formerly [5] sold under the brand name Compazine among others, is a medication used to treat nausea, migraines, schizophrenia, psychosis and anxiety. [6][7][8][9] It is a less preferred medication for anxiety. [6] It may be taken by mouth, rectally, injection into a vein, or injection into a muscle. [6]
Brotizolam [3] (marketed under brand name Lendormin) is a sedative-hypnotic [4] thienotriazolodiazepine [5] drug which is a benzodiazepine analog. [6] It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam. [7]
Levocetirizine, sold under the brand name Xyzal, among others, is a second-generation antihistamine used for the treatment of allergic rhinitis (hay fever) and long-term hives of unclear cause. [3] It is less sedating than older antihistamines. [4] It is taken by mouth. [3] Common side effects include sleepiness, dry mouth, cough, vomiting, and ...
Pizotifen. Glucuronidation (main route). N -glucuronide accounts for >50% of plasma and 60–70% of urinary excreted drug. Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene -based drug used as a medicine, primarily as a preventive to reduce the frequency of recurrent migraine headaches. [1]
The primary psychological effects have a duration of roughly 3 to 4 hours, with aftereffects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. [13] High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, [ 13 ] and there are anecdotal reports of psychosis from sleep ...
Dobutamine. Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure. [2][3] It may also be used in certain types of cardiac stress tests. [2] It is given by IV only, as an injection into a vein or intraosseous as a continuous infusion. [2]