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Patients should be supplemented with fat-soluble vitamins, and occasionally medium-chain triglycerides in order to improve growth. When liver synthetic dysfunction is significant, patients should be listed for transplantation. Family members should be tested for PFIC mutations, in order to determine risk of transmission. [citation needed]
Liver transplantation is the standard of care in people presenting with fulminant liver failure or those with the progression of disease despite multiple lines of therapy. [33] [34] [35] Many patients, once started on long-term immunosuppressive therapy, will remain on that treatment for life.
A medical condition is termed heterogeneous, or a heterogeneous disease, if it has several etiologies (root causes); as opposed to homogeneous conditions, which have the same root cause for all patients in a given group. Examples of heterogeneous conditions are hepatitis and diabetes. Heterogeneity is not unusual, as medical conditions are ...
The study focused on 16 U.S. children with severe hepatitis, analyzing samples of blood, stool and liver biopsies. In a majority of the cases, patients were infected with three or four common ...
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
Treatment of hepatomegaly varies with the cause, so accurate diagnosis is the first concern. In auto-immune liver disease, prednisone and azathioprine may be used for treatment. [3] In lymphoma the treatment options include single-agent (or multi-agent) chemotherapy and regional
Chronic liver disease is rare in children and adolescents; however, congenital liver disorders are associated with an increased the chance of developing HCC. [21] Specifically, children with biliary atresia , infantile cholestasis , glycogen-storage diseases , and other cirrhotic diseases of the liver are predisposed to developing HCC in childhood.
Pediatric end-stage liver disease (PELD) is a disease severity scoring system for children under 12 years of age. [1] It is calculated from the patient's albumin , bilirubin , and international normalized ratio (INR) together with the patient's age and degree of growth failure .